Blow-Fill-Seal (BFS) technology is the gold standard for aseptic filling of sterile liquid products — combining container formation, sterile filling, and sealing in a single automated step. Whether you’re manufacturing ophthalmics, respiratory treatments, or injectable solutions, a reliable sterile BFS CDMO ensures unmatched sterility, efficiency, and compliance.
With complete blow-fill-seal contract manufacturing capabilities, these CDMOs deliver scalable, GMP-compliant production of sterile single-dose and multi-dose containers for global markets.
Why Choose a CDMO for Blow-Fill-Seal
Partnering with an experienced BFS CDMO for sterile drugs offers:
- Integrated container formation and aseptic filling in ISO 5 conditions
- Minimal human intervention, reducing contamination risk
- Compatibility with unit-dose, multi-dose, and twist-off formats
- Support for ophthalmic, nasal, oral, injectable, and respiratory therapies
- Preservative-free system options
- Regulatory readiness (FDA, EMA, WHO PQ, etc.)
- Scalability from clinical to high-volume commercial batches
BFS is especially well-suited for sterile products where safety, speed, and format flexibility are essential.
Key Services Offered by Blow-Fill-Seal Contract Manufacturing Providers
Leading blow-fill-seal contract manufacturing companies typically offer:
- Formulation development for low-viscosity sterile liquids
- Container design and customization (LDPE, PP)
- Sterile BFS filling for volumes from 0.2 mL to 100 mL+
- Single-dose and multi-dose formats with tamper-evident designs
- Microbiological and particulate control testing
- Cold chain management, if required
- Labeling, secondary packaging, and serialization
- Regulatory support for ANDA, NDA, and EU submissions
These services support BFS products for ophthalmology, ENT, pulmonology, wound care, and more.
Advantages of Partnering with a BFS CDMO
Collaborating with a qualified BFS CDMO offers key benefits:
- Superior sterility assurance with closed-system processing
- Lower production costs due to high-speed automation
- Ideal for preservative-free products, especially for pediatric or ophthalmic use
- Reduced packaging waste and improved dosing accuracy
- Fast time to market with integrated fill-finish and packaging solutions
BFS is the solution of choice for high-volume, patient-friendly sterile liquids.
Sterile BFS CDMO Companies
Some of the most trusted sterile BFS CDMO providers include:
- Pharmaloop (a Salvat company): Fully integrated CDMO solutions for Blow-Fill-Seal (BFS), sterile multidose, non-sterile multi-dose, sachets, capsules, and tablets. [See CDMO profile]
- Adragos Pharma: Specialized in IV bags, plastic ampoules, and vials using BFS technology; sterile ophthalmic, nasal, and otic formats. [See CDMO profile]
- Liof Pharma S.L.U.: Aseptic manufacturing and lyophilization of biologics and injectable drugs. [See CDMO profile]
- ASCIL Biopharm: R&D and pharmaceutical development for technical and clinical batches of sterile products. [See CDMO profile]
- FAES FARMA: Developer and manufacturer of human medicinal products. [See CDMO profile]
- Huiyu Pharmaceuticals Co., Ltd: Development and production of complex dosage forms including implants, OSD, and sterile formulations. [See CDMO profile]
- Content Group: Manufacturing of sterile ophthalmic, nasal, and otic forms, and FDF/DRUG formulations. [See CDMO profile]
- i+Med: Developer of new drug products with controlled-release technologies including sterile presentations. [See CDMO profile]
- Cenexi: Specializes in manufacturing and filling of injectable and non-injectable sterile liquid products. [See CDMO profile]
- Aenova Group: Competence center for animal health products and advanced sterile technologies. [See CDMO profile]
- Basic Pharma: Tailored CDMO services for OSD and sterile ophthalmic formats. [See CDMO profile]
- Ophtapharm (Sentiss): Ophthalmic and otic solutions, suspensions, emulsions, ointments, and gels – FDA-approved facility. [See CDMO profile]
Related Information
Let MAI CDMO Help You Find the Right Sterile BFS CDMO Partner
At MAI CDMO, we connect pharma and biotech companies with the most experienced sterile BFS CDMO providers offering turnkey blow-fill-seal contract manufacturing. Whether you’re scaling a preservative-free therapy, launching a hospital-use product, or exploring unit-dose innovation, we’ll help you find a partner ready to deliver quality and compliance.
Ready to advance your sterile product with BFS technology? Contact us today and find your ideal CDMO partner.
