FDF / DRUG PRODUCTS BIOLOGICS SERVICES OLIGONUCLEOTIDES in Europe
Development and manufacturing of oral solid dose (OSD), nasal, inhalation, and sterile dry powders and liquids drug products.
About the plant
UK-based CDMO providing integrated contract development and manufacturing services. Specialising in oral, nasal, pulmonary and sterile dosage forms, the CDMO offers services that support the progression of a molecule from feasibility through formulation development, clinical trial manufacture and commercial manufacture.
Award-winning 60,000 sq.ft development and manufacturing facility in Nottingham, UK.
With over 25 years of experience, Upperton excels in rapid product introductions.
Our project delivery is unparalleled and designed to align with the values and innovation of small to mid-sized pharma companies.
We are flexible and nimble, enabling rapid decision-making, problem-solving, collaboration, and product introduction within 4–6 weeks.
With subject matter experts and leadership team oversight on every project, you can trust our delivery and expertise across all operations.
For small molecules and biologics, our clinical manufacturing process supports batch sizes from grams to kilograms.
One site advantage
60,000 sq.ft development and manufacturing facility in UK.
Development and manufacturing under one roof ensures smooth project progression. Knowledge remains within the same team, reducing handovers, maintaining clear communication, and minimising risk. By combining development, scale-up, QC and manufacturing in one location, we deliver an integrated, science-led approach that accelerates the journey from pre-clinical studies to clinic and market.
Our Manufacturing Capabilities at a Glance
- Up to 1,000,000 tableting capacity per day
- 500g–205kg blending capacity
- Up to 2,000 blister packaging units per day
- Up to 50kg tablet coating per batch
- Up to 350,000 capsule filling (powder) capacity per day
- Up to 1000kg dry granulation capacity per day
- 0.5g–10kg spray drying batch sizes (aqueous and solvent)
- 20 litres solution preparation vessel capacity with overhead mixing
- 10 state-of-the-art GMP manufacturing suites
Certifications
- MHRA (UK GMP)
Activity
- Abs (Antibodies), ADC & NDC (Antibody-drug), Peptide, protein, hormone & enzyme, Vaccines, Inhalation products, Oral liquids and semisolids, Oral solids / OSD, Sterile forms (ophtalmic, nasal, otic), Injectables, Powder, Nebulization, Bottles, Sprays, Oral solutions, Oral suspensions, Tablets, Hard capsules, Granules / Pellets, Powders, Terminal sterilization, Fill&Finish, Small volume vials, PFS (Prefilled Syringes), Cartridges, FDF / DRUG PRODUCTS, BIOLOGICS, SERVICES, OLIGONUCLEOTIDES manufacturing
Features
- Uses: Investigational, Commercial (Phase IV), Preclinical, Phase I, Phase II, Phase III, Human
- Toxicity (OEB classification): 1 / low-hazard (PDE > 5,000 µg/day), 2 (PDE = 1,000 - 5,000 µg/day), 3 (PDE = 100 - 1,000 µg/day), 4 / HPAPI (PDE = 10 - 100 µg/day), 5 / HPAPI (PDE < 10 µg/day)
- Controlled substance: High potential for abuse & no medical use, High potential for abuse & medical use, Lower potential for abuse, Low potential for abuse
- BSL: 1
- Therapeutic areas: (C) Cardiovascular system, (N) Nervous system, (R) Respiratory system
- Markets: FDA (USA), EMA (EU), Health Canada (Canada), MHRA (UK), TGA (Australia)
Batch Size / Reactor
- Small, Medium
Services
- Regulatory services, Development services, Manufacturing services, Analytical / QC services, Quality Assurance services, Packaging, Preformulation studies, R&D, Formulation / Galenic design, QbD (Quality by Design), Process development, Process optimization, Process validation, Stability studies design, Stability studies execution, ICH Stability studies, Comparability studies, Downstream, Fill&Finish, Sterile product manufacturing, Non sterile product manufacturing, Tech transfer, Pilot plant, Formulation mixing, Research batches, Engineering batches, Scale-up, Pilot batches, Registration batches, Batch records, Analytical methods development, Analytical methods validation, Analytical methods transfer, QP in house, Batch certification / release, GMP documentation, Primary packaging, Secondary packaging, Labeling, CMC regulatory support, IND (Investigational New Drug aplication) filing support, IMPD (Investigational Medicinal Product Dossier) submission support
