CZ Vaccines | CZ Vaccines | Large Scale Plant Spain

Manufacturing

Upstream

Cell and virus cultivation

Culture process in wave bioreactors

Single-use bioreactors:

• 2 x 50 L
• 3 x 200 L
• 3 x 2000 L

Blending mixer:

• Single-use tank 1 x 1500 L

Media preparation

Single-use mixers:

• 2 x 3000 L
• 2 x 2500 L
• 1 x 1000 L
• 2 x 650 L
• 1 x 200 L

Downstream and purification

Single-use mixers:

• 1 x 1500 L
• 1 x 650 L
• 1 x 500 L

Fill & Finish

Formulation and blending:

• 1 x 350 L single-use tanks
• 4 x 600 L stainless-steel tanks
• 1 x 3000 L single-use tank
• 4 x 6000 L stainless-steel tanks

2 filling lines: DARA machines

Capacity of each line based on vial size:

• Size 2R: 12,000 vials/hour
• Size 10R: 10,800 vials/hour
• Size 20R: 9,600 vials/hour

Automatic visual inspection: 2 x OPTREL machines

Storage: (+2 - +8°C), (-30°C) and (-80°C)

Combination of inhouse and subcontracted capacity for additional storage

2 double-door autoclaves connecting the washing and depyrogenation tunnels with each filling room